Extracellular Hsp90 and TGFP regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model

Title: Extracellular Hsp90 and TGFP regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model
Creator: de la Mare, Jo-Anne, Jurgens, Tamarin, Edkins, Adrienne L
Date: 2017
Type: article
Type: text
Identifier: http://hdl.handle.net/10962/59920
Identifier: vital:27710
Identifier: https://doi.org/10.1186/s12885-017-3190-z
Description: Tumour metastasis remains the major cause of death in cancer patients and, to date, the mechanism and signalling pathways governing this process are not completely understood. The TGF-ß pathway is the most commonly mutated pathway in cancer, however its role in cancer progression is controversial as it can function as both a promoter and a suppressor of metastasis. Although previous studies have suggested a role for the molecular chaperone Hsp90 in regulating the TGF-ß pathway, the level at which this occurs as well as the consequences in terms of colon cancer metastasis are unknown.
Format: 16 pages, pdf
Language: English
Relation: BMC Cancer, de la Mare, J.A., Jurgens, T. and Edkins, A.L., 2017. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. BMC cancer, 17(1), p.202, BMC Cancer 17 vol. 1 no. 1 16 2017 1471-2407
Rights: BMC Cancer
Rights: Use of this resource is governed by the terms and conditions of the bethesda Statement on Open Access Publishing

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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response

De la Mare, Jo-Anne (Dr)

Edkins, Adrienne Lesley (Associate Prof)

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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