- Title
- Stromatolite microbial communities as a source of new bioactive secondary metabolites
- Creator
- Flatt, P M, Damarjanan, C, Isamonger, E, Kalinski, Jarmo-Charles J, Dorrington, Rosemary A, McPhail, Kerry L
- Date
- 2016
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/65871
- Identifier
- vital:28851
- Identifier
- https://doi.org/10.1055/s-0036-1596638
- Description
- publisher version
- Description
- Stromatolites represent some of the earliest microbial communities on Earth. They are formed by accretion and precipitation of layered calcium carbonate structures that result from the metabolic activity of complex microbial communities and the geochemical conditions of their environment. Modern stromatolite communities include aerobic heterotrophs, sulphide-oxidizing bacteria, sulphate-reducing bacteria, fermentative bacteria and cyanobacteria. Phylogenetic analyses revealed the presence of new and known cyanobacterial taxa related to known producers of biologically active secondary metabolites in tufa stromatolites along the South African southeast coast [1]. Prompted us to investigate their potential for producing novel bioactive secondary metabolites. A series of three tide pools provided the opportunity to collect stromatolites along a vertical transect from pool A (highest elevation, low nitrogen input, fresh water), pool B (within high tide zone, brackish water) and pool C (within tidal zone). The microbial community in pool A is particularly distinct. Chemical extracts of stromatolites from different pools have been profiled by LC-MS/MS and the data subjected to molecular spectral networking using the GnPS platform [2] in order to establish the diversity and biological potential of the microbial metabolome that is being expressed within each of these microhabitats. Correlation of the phylogenetic and secondary metabolomic data is expected to guide the isolation of new natural products with biomedical relevance.
- Format
- Publisher
- Georg Thieme Verlag KG
- Language
- English
- Relation
- Planta Medica, Flatt, P M., Damarjanan, C., Isamonger, E., Kalinsky, R.A., Dorrington, Rosemary A. and McPhail, K. L. (2016) Stromatolite microbial communities as a source of new bioactive secondary metabolites. Planta Medica, 82 (S 01): S1-S381.https://doi.org/10.1055/s-0036-1596638, Planta Medica volume 82 number S01 S576 S576 2016 0032-0943
- Rights
- Thieme Planta Medica
- Rights
- Use of this resource is governed by the terms and conditions of the National Library of South Africa Copyright Act (http://www.nlsa.ac.za/downloads/Copyright Act.pdf)
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Collections
Dorrington, Rosemary A (Prof)
RU DST/NRF SARChI for Marine Natural Products
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
SDG 14. Life Below Water
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