- Title
- Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable carbonyl nitrile intermediate
- Creator
- Veale, Clinton G L, Edkins, Adrienne L, de la Mare, Jo-Anne, de Kock, Carmen, Smith, Peter J, Khanye, Setshaba D
- Date
- 2015
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/66221
- Identifier
- vital:28919
- Identifier
- https://doi.org/10.1016/j.tetlet.2015.02.090
- Description
- publisher version
- Description
- The synthesis of biologically relevant amides and esters is routinely conducted under complex reaction conditions or requires the use of additional catalysts in order to generate sensitive electrophilic species for attack by a nucleophile. Here we present the synthesis of different indolic esters and amides from indolyl-3-carbonyl nitrile, without the requirement of anhydrous reaction conditions or catalysts. Additionally, we screened these compounds for potential in vitro antimalarial and anticancer activity, revealing 1H-indolyl-3-carboxylic acid 3-(indolyl-3-carboxamide)aminobenzyl ester to have moderate activity against both lines.
- Format
- 5 pages, pdf
- Language
- English
- Relation
- Tetrahedron Letters, Veale, Clinton G.L., Edkins, Adrienne L., De la Mare, Jo-Anne, De Kock, Carmen, Smith, Peter J., Khanye, Setshaba D. (2015) Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable carbonyl nitrile intermediate. Tetrahedon Letters, 56 (14), p. 1860-1864. SN-0040-4039. https://doi.org/10.1016/j.tetlet.2015.02.090, Tetrahedron Letters volume 56 number 14 1860 1864 April 2015 0040-4039
- Rights
- Elsevier B.V.
- Rights
- Use of this resource is governed by the terms and conditions of the Tetrahedron Letters Open Access Options Statement (https://www.elsevier.com/journals/tetrahedron-letters/0040-4039/open-access-options)
- Hits: 2898
- Visitors: 3000
- Downloads: 142
Collections
RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
De la Mare, Jo-Anne (Dr)
Veale, Clinton G L (Dr)
Khanye, David Setshaba (Associate Prof)
RU Department of Chemistry
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | JPEG image | 975 KB | JPEG Image | View Details |