Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition.

Title: Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition.
Creator: Mbaba, Mziyanda, de la Mare, Jo-Anne, Sterrenberg, Jason N, Kajewole, Deborah, Maharaj, Shantal, Edkins, Adrienne L, Isaacs, Michelle, Hoppe, Heinrich C, Khanye, Setshaba D
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/122858
Identifier: vital:35359
Identifier: https://doi.org/10.1007/s00775-018-1634-9
Description: A series of tailored novobiocin–ferrocene conjugates was prepared in moderate yields and investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 breast cancer line and Plasmodium falciparum 3D7 strain, respectively. While the target compounds displayed moderate anticancer activity against the breast cancer cell line with IC50 values in the mid-micromolar range, compounds 10a–c displayed promising antiplasmodial activity as low as 0.889 µM. Furthermore, the most promising compounds were tested for inhibitory effects against a postulated target, heat shock protein 90 (Hsp90).
Format: 10 pages, pdf
Language: English
Relation: JBIC Journal of Biological Inorganic Chemistry
Rights: JBIC Journal of Biological Inorganic Chemistry
Rights: Use of this resource is governed by the SpringerLink Terms of Use Statement (https://link.springer.com/termsandconditions)

Collections

RU Department of Pharmacy

RU Centre for Chemico- and Biomedicinal Research (CCBR)

De la Mare, Jo-Anne (Dr)

Hoppe, Heinrich C (Prof)

Isaacs, Michelle (Mrs)

Khanye, David Setshaba (Associate Prof)

RU Department of Biochemistry, Microbiology and Biotechnology

Edkins, Adrienne Lesley (Associate Prof)

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