- Title
- Interacting motif networks located in hotspots associated with RNA release are conserved in Enterovirus capsids
- Creator
- Ross, Caroline J, Knox, Caroline M, Tastan Bishop, Özlem
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/124855
- Identifier
- vital:35704
- Identifier
- https://doi.10.1002/1873-3468.12663
- Description
- Enteroviruses are responsible for a multitude of human diseases. Expansion of the virus capsid is associated with a cascade of conformational changes that allow the subsequent release of RNA. For the first time, this study presents a comprehensive bioinformatic screen for the prediction of interacting motifs within intraprotomer interfaces and across respective interfaces surrounding the fivefold and twofold axes. The results identify a network of conserved motif residues involved in interactions in enteroviruses that may be critical to capsid stabilisation, providing guidelines towards developing antivirals that interfere with viral expansion during RNA release.
- Format
- 15 pages, pdf
- Language
- English
- Relation
- FEBS Letters, Ross, C., Knox, C. and Bishop, Ö.T., 2017. Interacting motif networks located in hotspots associated with RNA release are conserved in Enterovirus capsids. FEBS letters, 591(12), pp.1687-1701, FEBS Letters volume 591 number 12 1687 1701 2017 0014-5793
- Rights
- FEBS Letters
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Online Library Terms of Use statement (https://onlinelibrary.wiley.com/terms-and-conditions)
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Knox, Caroline (Prof)
RU Research Unit in Bioinformatics (RUBi)
Tastan Bishop, Ozlem (Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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