- Title
- Cationic cyclodextrin/alginate chitosan nanoflowers as 5-fluorouracil drug delivery system
- Creator
- Lakkakula, Jaya R, Matshaya, Thabo, Krause, Rui W M
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/125587
- Identifier
- vital:35798
- Identifier
- https://doi.org/10.1016/j.msec.2016.08.073
- Description
- Cyclodextrins (CDs) have widely been used as component of drug delivery systems. However unmodified cyclodextrins are associated with cytotoxicity and poor water solubility thus limiting their use in pharmaceutical industry. The cationic-β-cyclodextrin (Cat-β-CD) polymer cores were synthesized using β-CD, epichlorohydrin and choline chloride via a one-step polycondensation process. The main aim of this study was to synthesize hierarchical nanoflowers composed of cationic-β-CD as polymeric core along with alginate and chitosan “petals” (Cat-β-CD/Alg-Chi nanoflowers) as carriers for oral delivery of 5-Fluorouracil (5-FU) via an ionic-gelation technique. The drug loading capacity, particle size, zeta potential and surface morphology of the synthesized nanoflowers were determined. The prepared nanoflowers were formed with an average size of 300 nm and a zeta potential of + 9.90 mV with good encapsulation efficiency of up to 77.3%. In vitro release of 5-FU from the loaded nanoflowers showed controlled and sustained release compared to the inclusion complex alone. Cat-β-CD/Alg-Chi nanoflowers were assessed against L929 cells and found to be effectively inhibiting the growth of L929 cells in a concentration dependent manner.
- Format
- 8 pages, pdf
- Language
- English
- Relation
- Materials Science and Engineering: C, Lakkakula, J.R., Matshaya, T. and Krause, R.W.M., 2017. Cationic cyclodextrin/alginate chitosan nanoflowers as 5-fluorouracil drug delivery system. Materials Science and Engineering: C, 70, pp.169-177., Materials Science and Engineering: C number 70 169 177 2017 0928-4931
- Rights
- Materials Science and Engineering:C
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Krause, Rui Werner Maçedo (Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
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