- Title
- Three new pentacyclic triterpenoids from twigs of Manniophyton fulvum (Euphorbiaceae)
- Creator
- Mbeunkeu, Ahri B D, Noundou, Xavier S, Krause, Rui W M, Teinkela, Jean E M, Laatsch, Hartmut, Azebaze, Anatole G B, Vardamides, Juliette C, Tala, Michel F
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/126782
- Identifier
- vital:35922
- Identifier
- https://doi.org/10.1016/j.phytol.2018.06.019
- Description
- Phytochemical investigation of the methanol extracts of the twigs of Manniophyton fulvum has led to the isolation and characterization of three new pentacyclic triterpenoids, designated as 3α,28-dihydroxyfriedelan-1-one (1), manniotaraxerol A (3) and manniotaraxerol B (4), along with fourteen known compounds, 3α-hydroxy-1-oxofriedelane (2), betulinic acid (5), friedelin (S1), taraxerol (S2), a mixture of stigmasterol (S3) and β-sitosterol (S4), herranone (S5), docosanoic acid (S6), ursolic acid (S7), nasutin B (S8), bergenin (S9), stigmasterol-3-O-β-Dglucopyranoside (S10), 1,2-di-O-palmitoyl-3-O-(6-sulfo-α-D-quinovopyranosyl)glycerol (S11), and aridanin (S12). The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI and ESI-MS). 3α,28-Dihydroxyfriedelan-1-one (1), 3α-hydroxy-1-oxofriedelane (2), manniotaraxerol A (3), manniotaraxerol B (4), and betulinic acid (5) were evaluated against HeLa (human cervix adenocarcinoma) cancer cells. Manniotaraxerol A (3) showed weak in vitro cytotoxicity with a cell viability value of 49.3%. Betulinic acid (5) also showed significant cytotoxicity against HeLa cell with a cell viability value of 4.0%; the other compounds were inactive in this test.
- Format
- 8 pages, pdf
- Language
- English
- Relation
- Phytochemistry letters, Mbeunkeu, A.B.D., Azebaze, A.G.B., Tala, M.F., Teinkela, J.E.M., Noundou, X.S., Krause, R.W.M., Vardamides, J.C. and Laatsch, H., 2018. Three new pentacyclic triterpenoids from twigs of Manniophyton fulvum (Euphorbiaceae). Phytochemistry letters, 27, pp.1-8., Phytochemistry letters number 27 2018 1876-7486
- Rights
- Phytochemistry letters
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Krause, Rui Werner Maçedo (Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
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