Studies on the metabolism of SKF 525 A|

Title: Studies on the metabolism of SKF 525 A|
Creator: Barber, Peter John
ThesisAdvisor: Wilson, B.J.
Subject: Drugs -- Metabolism
Subject: Cytochrome P-450
Date: 1978
Date: 2013-10-14
Type: Thesis
Type: Masters
Type: MSc
Identifier: vital:3835
Identifier: http://hdl.handle.net/10962/d1007591
Identifier: Drugs -- Metabolism
Identifier: Cytochrome P-450
Description: Spectrophotometric studies have been carried out to determine the pH dependence of binding of SKF 525 A, Brietal sodium and carbon monoxide to cytochrome P-450. The optimal pH for metabolic conversion of SKF 525 A has been investigated and this agent and its major metabolite, SKF 8742 A, have been metabolised in vitro by swine and rat hepatic microsomes. A suitable gas liquid chromatography assay has been developed and used to analyse metabolic production. The effects of carbon monoxide, dithiothreitol, n-octylamine and of induction of cytochrome P-450 by phenobarbital on metabolism of SKF 525 A and SKF 8742 A have been investigated. Attempts have been made to synthesise SKF 525 AN-oxide.
Description: KMBT_363
Description: Adobe Acrobat 9.54 Paper Capture Plug-in
Format: 121 p., pdf
Publisher: Rhodes University, Faculty of Science, Pharmacy
Language: English
Rights: Barber, Peter John

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