- Title
- Studies on the metabolism of SKF 525 A|
- Creator
- Barber, Peter John
- ThesisAdvisor
- Wilson, B.J.
- Subject
- Drugs -- Metabolism
- Subject
- Cytochrome P-450
- Date
- 1978
- Date
- 2013-10-14
- Type
- Thesis
- Type
- Masters
- Type
- MSc
- Identifier
- vital:3835
- Identifier
- http://hdl.handle.net/10962/d1007591
- Identifier
- Drugs -- Metabolism
- Identifier
- Cytochrome P-450
- Description
- Spectrophotometric studies have been carried out to determine the pH dependence of binding of SKF 525 A, Brietal sodium and carbon monoxide to cytochrome P-450. The optimal pH for metabolic conversion of SKF 525 A has been investigated and this agent and its major metabolite, SKF 8742 A, have been metabolised in vitro by swine and rat hepatic microsomes. A suitable gas liquid chromatography assay has been developed and used to analyse metabolic production. The effects of carbon monoxide, dithiothreitol, n-octylamine and of induction of cytochrome P-450 by phenobarbital on metabolism of SKF 525 A and SKF 8742 A have been investigated. Attempts have been made to synthesise SKF 525 AN-oxide.
- Description
- KMBT_363
- Description
- Adobe Acrobat 9.54 Paper Capture Plug-in
- Format
- 121 p., pdf
- Publisher
- Rhodes University, Faculty of Science, Pharmacy
- Language
- English
- Rights
- Barber, Peter John
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