- Title
- Aspects of the bioavailability of topical corticosteroid formulations
- Creator
- Magnus, Ashley Denis
- Subject
- Adrenocortical hormones -- Therapeutic use
- Subject
- Dermatologic agents
- Subject
- Transdermal medication -- Evaluation
- Subject
- Dermatopharmacology
- Date
- 2013-02-12
- Type
- Thesis
- Type
- Masters
- Type
- MSc
- Identifier
- vital:3843
- Identifier
- http://hdl.handle.net/10962/d1009516
- Identifier
- Adrenocortical hormones -- Therapeutic use
- Identifier
- Dermatologic agents
- Identifier
- Transdermal medication -- Evaluation
- Identifier
- Dermatopharmacology
- Description
- Two possible variables of the McKenzie/Stoughton blanching assay, namely amount applied to the test site and occlusion time have been investigated. Subsequently, two topical steroid preparations, Synalar cream (0,025% fluocinolone acetonide) and Betnovate cream (0,1% betamethasone 17-valer ate) were extemporaneously diluted with five and six placebo bases respectively. Taking cognizance of the two possible variables, these diluted preparations were assessed in vivo using a modified version of the McKenzie/Stoughton blanching assay for blanching activity over a 14 month period. It was found that the base E45, which is slightly alkali, had the greatest effect on both preparations. In the case of betamethasone 17-valerate this base c aused the conversion to the less active isomer, betamethasone 21-valerate whereas at the end of the 14 month test period it was found that the Synalar/E45 dilution contained no fluocinolone acetonide. Quantitative analysis of all the diluted preparations by high performance liquid chromatography using a reverse-phase system was performed. The data obtained f r om the systematic stUdies of the effects of varying concentrations and occlusion times were presented at the Eleventh National Congress of the South African Pharmacological Society.
- Description
- KMBT_363
- Description
- Adobe Acrobat 9.53 Paper Capture Plug-in
- Format
- 125 p., pdf
- Publisher
- Rhodes University, Faculty of Pharmacy, Pharmacy
- Language
- English
- Rights
- Magnus, Ashley Denis
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RU Department of Pharmacy
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