- Title
- Human, vector and parasite Hsp90 proteins: a comparative bioinformatics analysis
- Creator
- Faya, Ngonidzashe, Penkler, David L, Tastan Bishop, Özlem
- Date
- 2015
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/148038
- Identifier
- vital:38704
- Identifier
- DOI: 10.1016/j.fob.2015.11.003
- Description
- The treatment of protozoan parasitic diseases is challenging, and thus identification and analysis of new drug targets is important. Parasites survive within host organisms, and some need intermediate hosts to complete their life cycle. Changing host environment puts stress on parasites, and often adaptation is accompanied by the expression of large amounts of heat shock proteins (Hsps). Among Hsps, Hsp90 proteins play an important role in stress environments. Yet, there has been little computational research on Hsp90 proteins to analyze them comparatively as potential parasitic drug targets. Here, an attempt was made to gain detailed insights into the differences between host, vector and parasitic Hsp90 proteins by large-scale bioinformatics analysis.
- Format
- 12 pages, pdf
- Language
- English
- Relation
- FEBS Open Bio, Faya, N., Penkler, D.L. and Bishop, Ö.T., 2015. Human, vector and parasite Hsp90 proteins: a comparative bioinformatics analysis. FEBS Open Bio, 5, pp.916-927., FEBS Open Bio volume 5 number 916 927 2015 2211-5463
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and conditions statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Tastan Bishop, Ozlem (Prof)
RU Research Unit in Bioinformatics (RUBi)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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| View Details | SOURCE1 | Human, vector and parasite Hsp90 proteins.pdf | 628 KB | Adobe Acrobat PDF | View Details |