- Title
- Unraveling the Motions behind Enterovirus 71 Uncoating:
- Creator
- Ross, Caroline J, Atilgan, Ali R, Tastan Bishop, Özlem, Atilgan, Canan
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/148158
- Identifier
- vital:38715
- Identifier
- DOI: 10.1016/j.bpj.2017.12.021
- Description
- Enterovirus 71 can be a severe pathogen in small children and immunocompromised adults. Virus uncoating is a critical step in the infection of the host cell; however, the mechanisms that control this process remain poorly understood. We applied normal mode analysis and perturbation response scanning to several complexes of the virus capsid and present a coarse-graining approach to analyze the full capsid. We show that our method offers an alternative to expressing the system as a set of rigid blocks and accounts for the interconnection between nodes within each subunit and protein interfaces across the capsid. In our coarse-grained approach, the modes associated with capsid expansion are captured in the first three nondegenerate modes and correspond to the changes observed in structural studies of the virus. We show that the resolution of the analysis may be modified without losing information on the global motions leading to uncoating.
- Format
- 17 pages, pdf
- Language
- English
- Relation
- Biophysical journal, Ross, C.J., Atilgan, A.R., Bishop, Ö.T. and Atilgan, C., 2018. Unraveling the motions behind enterovirus 71 uncoating. Biophysical journal, 114(4), pp.822-838., Biophysical journal volume 114 number 4 822 838 February 2018 1542-0086
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and conditions statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Tastan Bishop, Ozlem (Prof)
RU Research Unit in Bioinformatics (RUBi)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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