- Title
- No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations:
- Creator
- Kimuda, Magambo Phillip, Noyes, Harry, Mulindwa, Julius, Enyaru, John, Alibu, Vincent Pius, Sidibe, Issa, Mumba, Dieuodonne, Hertz-Fowler, Christiane, MacLeod, Annette, Tastan Bishop, Özlem, Matovu, Enock
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/148272
- Identifier
- vital:38725
- Identifier
- doi: 10.1371/journal.pntd.0006300
- Description
- Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken a candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether polymorphisms in IL10, IL8, IL4, HLAG, TNFA, TNX4LB, IL6, IFNG, MIF, APOL1, HLAA, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH have a role in HAT.
- Format
- 24 pages, pdf
- Language
- English
- Relation
- bioRxiv, Kimuda, M.P., Noyes, H., Mulindwa, J., Enyaru, J., Alibu, V.P., Sidibe, I., Mumba, D., Hertz-Fowler, C., MacLeod, A., Bishop, O.T. and Matovu, E., 2017. No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations. bioRxiv, p.180679., bioRxiv volume number p.180679 2017
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the bioRxiv Open Access Statement (https://www.biorxiv.org/about-biorxiv)
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Tastan Bishop, Ozlem (Prof)
RU Research Unit in Bioinformatics (RUBi)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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