- Title
- Quality by Design Optimization of Cold Sonochemical Synthesis of Zidovudine-Lamivudine Nanosuspensions:
- Creator
- Witika, Bwalya A, Smith, Vincent J, Walker, Roderick B
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/148424
- Identifier
- vital:38738
- Identifier
- https://doi.org/10.3390/pharmaceutics12040367
- Description
- Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used to manage HIV/AIDS infection. The compounds require frequent dosing, exhibit unpredictable bioavailability and a side effect profile that includes hepato- and haema-toxicity. A novel pseudo one-solvent bottom-up approach and Design of Experiments using sodium dodecyl sulphate (SDS) and α-tocopheryl polyethylene glycol succinate 1000 (TPGS 1000) to electrosterically stablize the nano co-crystals was used to develop, produce and optimize 3TC and AZT nano co-crystals. Equimolar solutions of 3TC in surfactant dissolved in de-ionised water and AZT in methanol were rapidly injected into a vessel and sonicated at 4 °C.
- Format
- 17 pages, pdf
- Language
- English
- Relation
- Pharmaceutics, Witika, B.A., Smith, V.J. and Walker, R.B., 2020. Quality by Design Optimization of Cold Sonochemical Synthesis of Zidovudine-Lamivudine Nanosuspensions. Pharmaceutics, 12(4), p.367., Pharmaceutics volume 12 number 4 p. 367 2020 1999-4923
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the MDPI Open Access Statement (https://www.int-res.com/journals/terms-of-use/)
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Walker, Roderick Bryan (Prof)
RU Department of Chemistry
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Quality by Design Optimization of Cold Sonochemical.pdf | 3 MB | Adobe Acrobat PDF | View Details Download |