- Title
- Simultaneous liposomal encapsulation of antibiotics and proteins: co-loading and characterization of rifampicin and Human Serum Albumin in soy-liposomes
- Creator
- Bapolisi, Alain M, Nkanga, Christian I, Walker, Roderick B, Krause, Rui W M
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/148617
- Identifier
- vital:38755
- Identifier
- https://doi.org/10.1016/j.jddst.2020.101751
- Description
- The recurrent development of resistance to antimicrobial agents threatens the ability for successful treatment of infectious diseases. Hydrophobic antibiotics such as rifampicin (Rif) are particularly affected due to poor bioavailability. On the other hand, proteins play important roles in drug delivery and release. Further, the combination of antimicrobials with therapeutic proteins and their encapsulation in liposomes seems a promising approach for improvement of antimicrobial efficacy. This study aimed to encapsulate Rif simultaneously with a large protein, Human Serum Albumin (HSA) in liposomes made from an inexpensive crude soy lecithin (CSL).
- Format
- 13 pages, pdf
- Language
- English
- Relation
- Journal of Drug Delivery Science and Technology, Bapolisi, A.M., Nkanga, C.I., Walker, R.B. and Krause, R.W.M., 2020. Simultaneous liposomal encapsulation of antibiotics and proteins: Co-loading and characterization of rifampicin and Human Serum Albumin in soy-liposomes. Journal of Drug Delivery Science and Technology, 58, p.101751., Journal of Drug Delivery Science and Technology volume 58 number p.101751 August 2020 1773-2247
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Walker, Roderick Bryan (Prof)
Krause, Rui Werner Maçedo (Prof)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
RU Department of Chemistry
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Simultaneous liposomal encapsulation of antibiotics and proteins.pdf | 623 KB | Adobe Acrobat PDF | View Details Download |