Polymerized serum albumin beads for use as slow-release adjuvants

Title: Polymerized serum albumin beads for use as slow-release adjuvants
Creator: Martin, Michelle Elizabeth Denny
ThesisAdvisor: Newman, J F E
Subject: Serum albumin
Subject: Antigens
Subject: Vaccines
Date: 1988
Type: Thesis
Type: Masters
Type: MSc
Identifier: vital:3879
Identifier: http://hdl.handle.net/10962/d1001613
Description: Experimental vaccines have been made by covalently bonding virus particles into polymerized rabbit serum albumin beads. Using Nodamura virus as a model antigen, these model vaccines induced specific humoral antibody production, comparable with that achieved using Freund's adjuvants. Virus specific antibodies were also induced when Nodamura virus was covalently attached to the bead surface using different crosslinkers. However, when poliovirus type 2 (Sabin strain) was polymerized into beads, the levels of neutralizing antibodies were insignificant compared with control aqueous vaccines. The synthetic immunostimulator, muramyl dipeptide, was included with bead vaccines in an attempt to potentiate the immune response. Immunostimulation is achieved by a slow release of antigen coinciding with the gradual breakdown of bead structure.
Format: 174 leaves, pdf
Publisher: Rhodes University, Faculty of Science, Biochemistry, Microbiology and Biotechnology
Language: English
Rights: Martin, Michelle Elizabeth Denny

Collections

RU Department of Biochemistry, Microbiology and Biotechnology (end of 2014)

		Thumbnail	File	Description	Size	Format
View Details			SOURCEPDF	PDF	14 MB	Adobe Acrobat PDF	View Details