The in vitro antiplasmodial and antiproliferative activity of new ferrocene-based α-aminocresols targeting hemozoin inhibition and DNA interaction:

Mbaba, Mziyanda; Dingle, Laura M K; Swart, Tarryn; Cash, Devon; Laming, Dustin; de la Mare, Jo-Anne; Taylor, Dale; Hoppe, Heinrich C; Biot, Christophe; Edkins, Adrienne L; Khanye, Setshaba D

Title: The in vitro antiplasmodial and antiproliferative activity of new ferrocene-based α-aminocresols targeting hemozoin inhibition and DNA interaction:
Creator: Mbaba, Mziyanda, Dingle, Laura M K, Swart, Tarryn, Cash, Devon, Laming, Dustin, de la Mare, Jo-Anne, Taylor, Dale, Hoppe, Heinrich C, Biot, Christophe, Edkins, Adrienne L, Khanye, Setshaba D
Date: 2020
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/149347
Identifier: vital:38827
Identifier: https://0-doi.org.wam.seals.ac.za/10.1002/cbic.202000132
Description: Compounds incorporating ferrocene in a aminocresol scaffold showed antiplasmodial and anticancer activity. SAR studies revealed that an OH group and rotatable C–NH bond are vital for biological activity, with spectrophotometric techniques and docking simulations suggesting a dual mode of action involving hemozoin inhibition and DNA interaction. Targeting multiple pathways could delay the development of clinical resistance.
Format: 17 pages, pdf
Language: English
Relation: ChemBioChem, Mbaba, M., Dingle, L.M., Swart, T., Cash, D., Laming, D., de la Mare, J.A., Taylor, D., Hoppe, H.C., Biot, C., Edkins, A.L. and Khanye, S.D., 2020. The in vitro antiplasmodial and antiproliferative activity of new ferrocene‐based α‐aminocresols targeting hemozoin inhibition and DNA interaction. ChemBioChem., ChemBioChem volume number April 2020 1439-7633
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Chemistry Europe Terms of use Statement (https://0-onlinelibrary.wiley.com.wam.seals.ac.za/terms-and-conditions)

Hits: 4944
Visitors: 5035
Downloads: 144

Collections