Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic Arylpyrrole-Based Chalcone derivatives:

Zulu, Ayanda I; Oderinlo, Ogunyemi O; Kruger, Cuan; Isaacs, Michelle; Hoppe, Heinrich C; Smith, Vincent J; Veale, Clinton G L; Khanye, Setshaba D

Title: Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic Arylpyrrole-Based Chalcone derivatives:
Creator: Zulu, Ayanda I, Oderinlo, Ogunyemi O, Kruger, Cuan, Isaacs, Michelle, Hoppe, Heinrich C, Smith, Vincent J, Veale, Clinton G L, Khanye, Setshaba D
Date: 2020
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/179017
Identifier: vital:40096
Identifier: https://doi.org/10.3390/molecules25071668
Description: With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields. The resultant compounds were evaluated in vitro for their potential activity against a cultured Trypanosoma brucei brucei 427 strain. Several compounds displayed mostly modest in vitro anti-trypanosomal activity with compounds 10e and 10h emerging as active candidates with IC50 values of 4.09 and 5.11 µM, respectively. More importantly, a concomitant assessment of their activity against a human cervix adenocarcinoma (HeLa) cell line revealed that these compounds are non-toxic.
Format: 16 pages, pdf
Language: English
Relation: Molecules, Zulu, A.I., Oderinlo, O.O., Kruger, C., Isaacs, M., Hoppe, H.C., Smith, V.J., Veale, C.G. and Khanye, S.D., 2020. Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic Arylpyrrole-Based Chalcone derivatives. Molecules, 25(7), p.1668, Molecules volume 25 number 7 p.1668 April 2020 1420-3049
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the MDPI Open Access Statement (https://www.int-res.com/journals/terms-of-use/)

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Smith, Vincent J (Dr)

Khanye, David Setshaba (Associate Prof)

RU Centre for Chemico- and Biomedicinal Research (CCBR)

Hoppe, Heinrich C (Prof)

Isaacs, Michelle (Mrs)

RU Department of Chemistry

RU Department of Pharmacy

SDG 03. Good Health and Well-Being

RU Department of Biochemistry, Microbiology and Bioinformatics

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