- Title
- Allosteric site modulators: a case study for falcipains as malarial drug targets
- Creator
- Musyoka, Thommas M, Tastan Bishop, Özlem
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/162699
- Identifier
- vital:40974
- Identifier
- https://doi.org/10.21955/gatesopenres.1116459.1
- Description
- Fighting against malaria is a never-ending battle. Plasmodium parasites continuously develop resistance to the drugs used against them including the artemisinin-based combination therapies as observed recently in Southeast Asia. The main concern now is whether the resistant parasite strains spread to Africa, where most malaria cases are located. To prevent this, we need to think outside the box. To date, there is no allosteric drug for malaria. Hence, allosteric drug targeting sites and modulators might be a new hope for malarial treatment. In Plasmodium falciparum two cysteine proteases, falcipain-2 (FP-2) and falcipain-3 (FP-3), have been identified as the main hemoglobinases, and are considered as attractive drug targets.
- Format
- 1 page, pdf
- Language
- English
- Relation
- Gates Open Research, Musyoka, T. and Bishop, O.T., 2019. Allosteric site modulators: A case study for falcipains as malarial drug targets. Gates Open Res, 3., Gates Open Research volume 3 number 1 1 October 2019 2572-4754
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Gates Open Research Statement (https://gatesopenresearch.org/about)
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Tastan Bishop, Ozlem (Prof)
RU Research Unit in Bioinformatics (RUBi)
SDG 03. Good Health and Well-Being
RU Department of Biochemistry, Microbiology and Bioinformatics
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Allosteric site modulators.pdf | 3 MB | Adobe Acrobat PDF | View Details Download |