Semi-synthesis and evaluation of sargahydroquinoic acid derivatives as potential antimalarial agents:

Title: Semi-synthesis and evaluation of sargahydroquinoic acid derivatives as potential antimalarial agents:
Creator: Munedzimwe, Tatenda C, van Zyl, Rovyn L, Heslop, Donovan C, Edkins, Adrienne L, Beukes, Denzil R
Date: 2019
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/163456
Identifier: vital:41040
Identifier: DOI: 10.3390/medicines6020047
Description: Malaria continues to present a major health problem, especially in developing countries. The development of new antimalarial drugs to counter drug resistance and ensure a steady supply of new treatment options is therefore an important area of research. Meroditerpenes have previously been shown to exhibit antiplasmodial activity against a chloroquinone sensitive strain of Plasmodium falciparum (D10). In this study we explored the antiplasmodial activity of several semi-synthetic analogs of sargahydroquinoic acid.
Format: pdf
Language: English
Relation: Medicines, Munedzimwe, T.C., Van Zyl, R.L., Heslop, D.C., Edkins, A.L. and Beukes, D.R., 2019. Semi-synthesis and evaluation of sargahydroquinoic acid derivatives as potential antimalarial agents. Medicines, 6(2), p.47, Medicines volume 6 number 2 1 9 February 2019 2305-6320
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the MDPI Open Access Statement (https://www.int-res.com/journals/terms-of-use/)

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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response

Edkins, Adrienne Lesley (Associate Prof)

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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