- Title
- Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective
- Creator
- Edkins, Adrienne L, Price, John T, Pockley, A Graham, Blatch, Gregory L
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/164332
- Identifier
- vital:41109
- Identifier
- DOI: 10.1098/rstb.2016.0521
- Description
- Many heat shock proteins (HSPs) are essential to survival as a consequence of their role as molecular chaperones, and play a critical role in maintaining cellular proteostasis by integrating the fundamental processes of protein folding and degradation. HSPs are arguably among the most prominent classes of proteins that have been broadly linked to many human disorders, with changes in their expression profile and/or intracellular/extracellular location now being described as contributing to the pathogenesis of a number of different diseases. Although the concept was initially controversial, it is now widely accepted that HSPs have additional biological functions over and above their role in proteostasis (so-called ‘protein moonlighting’).
- Format
- 8 pages, pdf
- Language
- English
- Relation
- PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B, Edkins AL, Price JT, Pockley AG, Blatch GL. 2017 Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective. Phil. Trans. R. Soc. B 373: 20160521. http://dx.doi.org/10.1098/rstb.2016.0521, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B volume 373 number 1738 1 7 December 2017 1471-2970
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Royal Society Publishing Terms and Conditions Statement (https://royalsociety.org/about-us/terms-conditions-policies/)
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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
Edkins, Adrienne Lesley (Associate Prof)
Blatch, Gregory Lloyd (Prof)
SDG 03. Good Health and Well-Being
RU Department of Biochemistry, Microbiology and Bioinformatics
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