- Title
- Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins
- Creator
- Baindur-Hudson, Swati, Edkins, Adrienne L, Blatch, Gregory L
- Date
- 2015
- Type
- text
- Type
- book
- Identifier
- http://hdl.handle.net/10962/164852
- Identifier
- vital:41178
- Identifier
- ISBN 978-3-319-11730-0
- Identifier
- DOI: 10.1007/978-3-319-11731-7_3
- Description
- The Hsp70/Hsp90 organising protein (Hop), also known as stress-inducible protein 1 (STI1), has received considerable attention for diverse cellular functions in both healthy and diseased states. There is extensive evidence that intracellular Hop is a co-chaperone of the major chaperones Hsp70 and Hsp90, playing an important role in the productive folding of Hsp90 client proteins. Consequently, Hop is implicated in a number of key signalling pathways, including aberrant pathways leading to cancer. However, Hop is also secreted and it is now well established that Hop also serves as a receptor for the prion protein, PrPC.
- Format
- 22 pages, pdf
- Publisher
- Springer
- Language
- English
- Relation
- Baindur-Hudson, S., Edkins, A.L. and Blatch, G.L., 2015. Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins. In The Networking of Chaperones by Co-chaperones (pp. 69-90). Springer, Cham
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
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Edkins, Adrienne Lesley (Associate Prof)
Blatch, Gregory Lloyd (Prof)
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RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Hsp70Hsp90 organising protein (hop).pdf | 576 KB | Adobe Acrobat PDF | View Details |