- Title
- Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins
- Creator
- Baindur-Hudson, Swati, Edkins, Adrienne L, Blatch, Gregory L
- Date
- 2015
- Type
- text
- Type
- book
- Identifier
- http://hdl.handle.net/10962/164852
- Identifier
- vital:41178
- Identifier
- ISBN 978-3-319-11730-0
- Identifier
- DOI: 10.1007/978-3-319-11731-7_3
- Description
- The Hsp70/Hsp90 organising protein (Hop), also known as stress-inducible protein 1 (STI1), has received considerable attention for diverse cellular functions in both healthy and diseased states. There is extensive evidence that intracellular Hop is a co-chaperone of the major chaperones Hsp70 and Hsp90, playing an important role in the productive folding of Hsp90 client proteins. Consequently, Hop is implicated in a number of key signalling pathways, including aberrant pathways leading to cancer. However, Hop is also secreted and it is now well established that Hop also serves as a receptor for the prion protein, PrPC.
- Format
- 22 pages, pdf
- Publisher
- Springer
- Language
- English
- Relation
- Baindur-Hudson, S., Edkins, A.L. and Blatch, G.L., 2015. Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins. In The Networking of Chaperones by Co-chaperones (pp. 69-90). Springer, Cham
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
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Collections
RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
Edkins, Adrienne Lesley (Associate Prof)
RU Books and Book Chapters
Blatch, Gregory Lloyd (Prof)
SDG 03. Good Health and Well-Being
RU Department of Biochemistry, Microbiology and Bioinformatics
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Hsp70Hsp90 organising protein (hop).pdf | 576 KB | Adobe Acrobat PDF | View Details |