LRP1 is required for novobiocin-mediated fibronectin turnover:

Title: LRP1 is required for novobiocin-mediated fibronectin turnover:
Creator: Boel, Natasha M-E, Hunter, Morgan C, Edkins, Adrienne L
Date: 2018
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/164896
Identifier: vital:41182
Identifier: DOI: 10.1038/s41598-018-29531-2
Description: Fibronectin (FN) plays a major role in the stability and organization of the extracellular matrix (ECM). We have previously demonstrated that FN interacts directly with Hsp90, as well as showing that the Hsp90 inhibitor novobiocin results in FN turnover via a receptor mediated process. However, the receptor involved has not been previously identified. LRP1 is a ubiquitous receptor responsible for the internalisation of numerous ligands that binds both Hsp90 and FN, and therefore we investigated whether LRP1 was involved in novobiocin-mediated FN turnover.
Format: 15 pages, pdf
Language: English
Relation: Scientific reports, Boel, N.M.E., Hunter, M.C. and Edkins, A.L., 2018. LRP1 is required for novobiocin-mediated fibronectin turnover. Scientific reports, 8(1), pp.1-14, Scientific reports volume 8 number 1 1 14 May 2018 2045-2322
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the PLOSOne Terms of Use Statement (https://www.plos.org/terms-of-use )

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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response

Edkins, Adrienne Lesley (Associate Prof)

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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