- Title
- SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines:
- Creator
- Acharya, Mridu, Edkins, Adrienne L, Ozanne, B, Cushley, W
- Date
- 2009
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/165044
- Identifier
- vital:41204
- Identifier
- DOI: 10.1038/leu.2009.126
- Description
- CD23 acts through the αvβ5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. αvβ5 is expressed on normal B-cell precursors in the bone marrow. Soluble CD23 (sCD23), short CD23-derived peptides containing the arg-lys-cys (RKC) motif recognized by αvβ5 and anti-αvβ5 monoclonal antibodies (MAbs) all sustain growth of pre-B cell lines. The chemokine stromal cell-derived factor-1 (SDF-1) regulates key processes during B-cell development. SDF-1 enhanced the growth-sustaining effect driven by ligation of αvβ5 with anti-αvβ5 MAb 15F-11, sCD23 or CD23-derived RKC-containing peptides. This effect was restricted to B-cell precursors and was specific to SDF-1.
- Format
- 12 pages, pdf
- Language
- English
- Relation
- Leukemia, Acharya, M., Edkins, A.L., Ozanne, B.W. and Cushley, W., 2009. SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines. Leukemia, 23(10), pp.1807-1817, Leukemia volume 23 number 10 1 11 July 2009 1476-5551
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Nature Terms and Conditions Statement (https://www.nature.com/info/terms-and-conditions)
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RU Department of Biochemistry, Microbiology and Biotechnology
Edkins, Adrienne Lesley (Associate Prof)
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