- Title
- Cancer stem cells in breast cancer and metastasis:
- Creator
- Lawson, Jessica C, Blatch, Gregory L, Edkins, Adrienne L
- Date
- 2009
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/165057
- Identifier
- vital:41205
- Identifier
- DOI: 10.1007/s10549-009-0524-9
- Description
- The cancer stem cell theory poses that cancers develop from a subset of malignant cells that possess stem cell characteristics and has been proposed to account for the development of a variety of malignancies, including breast cancer. These cancer stem cells (CSC) possess characteristics of both stem cells and cancer cells, in that they have the properties of self-renewal, asymmetric cell division, resistance to apoptosis, independent growth, tumourigenicity and metastatic potential. A CSC origin for breast cancer can neatly explain both the heterogeneity of breast cancers and the relapse of the tumours after treatment. However, many reports on CSC in the breast are contradictory. There is variation with respect to how breast cancer stem cells should be identified, their characteristics and a possible lack of correlation between clinical outcome and breast cancer stem cell status of a tumour. These combined factors have made breast cancer stem cells a highly contentious issue. In this review, we highlight the progress in the analysis of cancer stem cells, with an emphasis on breast cancer.
- Format
- 14 pages, pdf
- Language
- English
- Relation
- Breast cancer research and treatment, Lawson, J.C., Blatch, G.L. and Edkins, A.L., 2009. Cancer stem cells in breast cancer and metastasis. Breast cancer research and treatment, 118(2), pp.241-254, Breast cancer research and treatment volume 118 number 2 241 254 September 2009 1573-7217
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement (https://link.springer.com/termsandconditions)
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Edkins, Adrienne Lesley (Associate Prof)
Blatch, Gregory Lloyd (Prof)
RU Department of Biochemistry, Microbiology and Bioinformatics
SDG 03. Good Health and Well-Being
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