- Title
- Differential regulation of monocyte cytokine release by αV and β2 integrins that bind CD23:
- Creator
- Edkins, Adrienne L, Borland, Gillian, Acharya, Mridu, Cogdell, Richard, Ozanne, Bradford W, Cushley, William
- Date
- 2012
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/165153
- Identifier
- vital:41213
- Identifier
- DOI: 10.1111/j.1365-2567.2012.03576.x
- Description
- The human soluble CD23 (sCD23) protein displays highly pleiotropic cytokine‐like activity. Monocytic cells express the sCD23‐binding integrins αVβ3, αVβ5, αMβ2 and αXβ2, but it is unclear which of these four integrins most acutely regulates sCD23‐driven cytokine release. The hypothesis that ligation of different sCD23‐binding integrins promoted release of distinct subsets of cytokines was tested. Lipopolysaccharide (LPS) and sCD23 promoted release of distinct groups of cytokines from the THP‐1 model cell line.
- Format
- 11 pages, pdf
- Language
- English
- Relation
- Immunology, Edkins, A.L., Borland, G., Acharya, M., Cogdell, R.J., Ozanne, B.W. and Cushley, W., 2012. Differential regulation of monocyte cytokine release by αV and β2 integrins that bind CD23. Immunology, 136(2), pp.241-251, Immunology volume 136 number 2 241 251 February 2012 1365-2567
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
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Edkins, Adrienne Lesley (Associate Prof)
SDG 03. Good Health and Well-Being
RU Department of Biochemistry, Microbiology and Bioinformatics
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