Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro:

de la Mare, Jo-Anne; Lawson, Jessica C; Chiwakata, Maynard T; Beukes, Denzil R; Blatch, Gregory L; Edkins, Adrienne L

Title: Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro:
Creator: de la Mare, Jo-Anne, Lawson, Jessica C, Chiwakata, Maynard T, Beukes, Denzil R, Blatch, Gregory L, Edkins, Adrienne L
Date: 2012
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/165165
Identifier: vital:41214
Identifier: DOI: 10.1007/s10637-011-9788-0
Description: Red and brown algae have been shown to produce a variety of compounds with chemotherapeutic potential. A recent report described the isolation of a range of novel polyhalogenated monoterpene compounds from the red algae Plocamium corallorhiza and Plocamium cornutum collected off the coast of South Africa, together with the previously described tetraprenylquinone, sargaquinoic acid (SQA), from the brown algae Sargassum heterophyllum. In our study, the algal compounds were screened for anti-proliferative activity against metastatic MDA-MB-231 breast cancer cells revealing that a number of compounds displayed anti-cancer activity with IC50 values in the micromolar range. A subset of the compounds was tested for differential toxicity in the MCF-7/MCF12A system and five of these, including sargaquinoic acid, were found to be at least three times more toxic to the breast cancer than the non-malignant cell line.
Format: 15 pages, pdf
Language: English
Relation: Investigational new drugs, de la Mare, J.A., Lawson, J.C., Chiwakata, M.T., Beukes, D.R., Edkins, A.L. and Blatch, G.L., 2012. Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro. Investigational new drugs, 30(6), pp.2187-2200, Investigational new drugs volume 30 number 6 2187 2200 January 2012 1573-0646
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)

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Beukes, Denzil Ronwynne (Prof)

De la Mare, Jo-Anne (Dr)

Edkins, Adrienne Lesley (Associate Prof)

Blatch, Gregory Lloyd (Prof)

RU Department of Pharmacy

SDG 03. Good Health and Well-Being

RU Department of Biochemistry, Microbiology and Bioinformatics

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