- Title
- A comparative study of the effect of different stabilizers on the critical quality attributes of self-assembling nano co-crystals
- Creator
- Witika, Bwalya A, Smith, Vincent J, Walker, Roderick B
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/183224
- Identifier
- vital:43931
- Identifier
- xlink:href=" https://doi.org/10.3390/pharmaceutics12020182"
- Description
- Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used orally to manage HIV/AIDS infection. A pseudo one-solvent bottom-up approach was used to develop and produce nano co-crystals of 3TC and AZT. Equimolar amounts of 3TC dissolved in de-ionized water and AZT in methanol were rapidly injected into a pre-cooled vessel and sonicated at 4 °C. The resultant suspensions were characterized using a Zetasizer. The particle size, polydispersity index and Zeta potential were elucidated. Further characterization was undertaken using powder X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and energy dispersive X-ray spectroscopy scanning electron microscopy. Different surfactants were assessed for their ability to stabilize the nano co-crystals and for their ability to produce nano co-crystals with specific and desirable critical quality attributes (CQA) including particle size (PS) less than 1000 nm, polydispersity index (PDI) less than 0.500 and Zeta potential (ZP) less than −30 mV. All surfactants produced co-crystals in the nanometer range. The PDI and PS are concentration-dependent for all nano co-crystals manufactured while only ZP was within specification when sodium dodecyl sulfate was used in the process.
- Format
- computer, online resource, application/pdf, 1 online resource (15 pages), pdf
- Publisher
- MDPI
- Language
- English
- Relation
- Pharmaceutics, Witika, B.A., Smith, V.J. and Walker, R.B., 2020. A comparative study of the effect of different stabilizers on the critical quality attributes of self-assembling nano co-crystals. Pharmaceutics, 12(2), p.182, Pharmaceutics volume 12 number 2 p. 182 2020 1999-4923
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the MDPI Open Access Statement (https://www.int-res.com/journals/terms-of-use/)
- Rights
- Open Access
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Collections
Smith, Vincent J (Dr)
Walker, Roderick Bryan (Prof)
RU Department of Chemistry
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
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