- Title
- Preformulation studies of efavirenz with lipid excipients using thermal and spectroscopic techniques
- Creator
- Makoni, Pedzisai A, Kasongo, Kasongo W, Walker, Roderick B
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/183253
- Identifier
- vital:43934
- Identifier
- xlink:href=" https://doi.org/10.1691/ph.2020.0053"
- Description
- Investigation and identification of potential lipids for the manufacture of efavirenz loaded solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) was undertaken. Polymorphic modification and characteristics of the lipids with the best solubilising potential for efavirenz was explored using Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and Wide-angle X-ray Scattering (WAXS). Lipid screening revealed that EFV is highly soluble in solid and liquid lipids, with glyceryl monostearate (GM) and Transcutol® HP (THP) exhibiting the best solubilising potential for EFV. GM exists in a stable β-polymorphic modification prior to exposure to heat, but exists in an α-polymorphic modification following exposure to heat. However, it was established that the addition of THP to GM revealed the co-existence of the α- and β'-polymorphic modifications of the lipid. EFV (60% w/w) exists in a crystalline state in a 70:30 mixture of GM and THP. Investigation of binary mixtures of EFV/GM and GM/THP, in addition to eutectic mixtures of EFV, GM and THP using FT-IR, DSC and WAXS revealed no potential interactions between EFV and the lipids selected for the production of the nanocarriers.
- Format
- computer, online resource, application/pdf, 1 online resource (7 pages), pdf
- Publisher
- Avoxa - Mediengruppe Deutscher Apotheker GmbH
- Language
- English
- Relation
- Die Pharmazie-An International Journal of Pharmaceutical Sciences, Makoni, P.A., Kasongo, K.W. and Walker, R.B., 2020. Preformulation studies of efavirenz with lipid excipients using thermal and spectroscopic techniques. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 75(9), pp.417-423, Die Pharmazie-An International Journal of Pharmaceutical Sciences volume 75 number 9 p. 417 2020 0031-7144
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Creative Commons CC BY-NC-ND 4.0 License (Attribution-NonCommercial-NoDerivatives 4.0 International) https://creativecommons.org/licenses/by-nc-nd/4.0/
- Rights
- Open Access
- Hits: 1480
- Visitors: 1686
- Downloads: 239
Collections
Walker, Roderick Bryan (Prof)
Makoni, Pedzisai A (Dr)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Preformulation studies of efavirenz with lipid excipients using thermal and spectroscopic techniques.pdf | 1 MB | Adobe Acrobat PDF | View Details |