- Title
- Encapsulation and physicochemical evaluation of efavirenz in liposomes
- Creator
- Okafor, Nnamdi Ikemefuna, Nkanga, Christian I, Walker, Roderick B, Noundou, Xavier S, Krause, Rui W M
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/183414
- Identifier
- vital:43988
- Identifier
- xlink:href="https://doi.org/10.1007/s40005-019-00458-8"
- Description
- Antiretroviral therapy remains the most efective means of managing the human immune defciency virus/acquired immune defciency syndrome (HIV/AIDS). Application of therapeutics has been hampered by factors including poor bioavailability of most anti-retroviral compounds (ARV), side efects and an alarming emergence of drug resistant strains of the virus. Recent developments and use of drug delivery systems (DDS) has shown potential for improving the pharmacological profle of ARV. Amongst these complex DDS, liposomes have been explored for delivery of ARV. In this study, we have aimed at exploring efcient encapsulation of efavirenz (EFV), a potent ARV using diferent mass ratios of crude soybean lecithin and cholesterol. The EFV-loaded liposomes (EFL) were prepared using thin flm hydration and evaluated for particle size, zeta potential (ZP), encapsulation efciency (EE%), morphology and drug release studies. Diferential scanning calorimetry (DSC), X-ray difraction (XRD), energy dispersity spectroscopy (EDS) and Fourier transform infrared (FTIR) spectroscopy were used for comprehensive physicochemical characterization of EFL. EFL exhibited high encapsulation (99%) in 1:1 crude lecithin to cholesterol mass ratio. The average particle size and Zeta Potential of EFL were found to be 411.10±7.40 nm and −53.5.3±0.06 mV, respectively. EFL showed a relatively controlled EFV release behaviour that was similar to the dissolution profle of un-encapsulated EFV. This suggests that EFL represents a promising vehicle for efective EFV delivery while providing the advantages of a nano-scaled delivery system
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- SpringerLink
- Language
- English
- Relation
- EJournal of Pharmaceutical Investigation, Okafor, N.I., Nkanga, C.I., Walker, R.B., Noundou, X.S. and Krause, R.W.M., 2020. Encapsulation and physicochemical evaluation of efavirenz in liposomes. Journal of Pharmaceutical Investigation, 50(2), pp.201-208, EJournal of Pharmaceutical Investigation volume 50 number 2 p. 201 2020 2093-6214
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
- Rights
- Open Access
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Collections
Walker, Roderick Bryan (Prof)
Krause, Rui Werner Maçedo (Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Encapsulation and physicochemical evaluation of efavirenz in liposomes.pdf | 923 KB | Adobe Acrobat PDF | View Details |