- Title
- Co-encapsulation of rifampicin and isoniazid in crude soybean lecithin liposomes
- Creator
- Nkanga, Christian I, Noundou, Xavier S, Walker, Roderick B, Krause, Rui W M
- Subject
- To be catalogued
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/183536
- Identifier
- vital:44005
- Identifier
- xlink:href="https://doi.org/10.17159/0379-4350/2019/v72a11"
- Description
- Despite the well-known anti-mycobacterial actions of isoniazid (INH) and rifampicin (RIF), the clinical success of tuberculosis (TB) therapy requires prolonged administration of multiple drugs in high doses, which often result in frequent adverse effects and low patient adherence. Although liposomes are promising candidates for controlled delivery of anti-TB drug, the high cost of synthetic and highly purified natural lipids currently used in liposomal technology might preclude the universal application of therapeutic liposomes. This work aimed at evaluating the potential of a cost-effective lipid material, crude soybean lecithin (CL), to co-encapsulate RIF and INH for liposomal dual delivery. RIF was encapsulated in CL-liposomes with/without cholesterol using film hydration method, after which INH was incorporated using a freeze–thawing technique. Dynamic light scattering, differential scanning calorimetry, X-ray diffraction and dialysis were used for liposome characterization. Liposomes containing CL alone (CLL) exhibited 90%encapsulation efficiency for RIF and 59%for INH. The mean size and surface charge of CLL were 1114nm and –63mV, respectively. In addition, CLL showed a controlled release profile for the co-encapsulated drugs. CLL would be promising vehicles for macrophage-targeting drug delivery. The present findings demonstrate the feasibility of using CL for preparation of combination products for liposomal delivery.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- Sabinet
- Language
- English
- Relation
- South African Journal of Chemistry, Nkanga, C.I., Noundou, X.S., Walker, R.B. and Krause, R.W., 2019. Co-encapsulation of rifampicin and isoniazid in crude soybean lecithin liposomes. South African Journal of Chemistry, 72, pp.80-87, South African Journal of Chemistry volume 72 p. 80 2019 0379-4350
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Sabinet Terms and Conditions Statement (https://www.sabinet.co.za/terms-conditions)
- Rights
- Open Access
- Hits: 1783
- Visitors: 1935
- Downloads: 172
Collections
Walker, Roderick Bryan (Prof)
Krause, Rui Werner Maçedo (Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Co-encapsulation of rifampicin and isoniazid in crude soybean lecithin liposomes.pdf | 1 MB | Adobe Acrobat PDF | View Details Download |