- Title
- The impact of manufacturing variables on in vitro release of clobetasol 17-propionate from pilot scale cream formulations
- Creator
- Fauzee, Ayesha F B, Khamanga, Sandile M, Walker, Roderick B
- Subject
- To be catalogued
- Date
- 2014
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/183872
- Identifier
- vital:44077
- Identifier
- xlink:href="https://doi.org/10.3109/03639045.2013.842579"
- Description
- The purpose of the study was to evaluate the effect of different homogenization speeds and times, anchor speeds and cooling times on the viscosity and cumulative % clobetasol 17-propionate released per unit area at 72 h from pilot scale cream formulations. A 24 full factorial central composite design for four independent variables were investigated. Thirty pilot scale batches of cream formulations were manufactured using a Wintech® cream/ointment plant. The viscosity and in vitro release of CP were monitored and compared to an innovator product that is commercially available on the South African market, namely, Dermovate® cream. Contour and three-dimensional response surface plots were produced and the viscosity and cumulative % CP released per unit area at 72 h were found to be primarily dependent on the homogenization and anchor speeds. An increase in the homogenization and anchor speeds appeared to exhibit a synergistic effect on the resultant viscosity of the cream whereas an antagonistic effect was observed for the in vitro release of CP from the experimental cream formulations. The in vitro release profiles were best fitted to a Higuchi model and diffusion proved to be the dominant mechanism of drug release that was confirmed by use of the Korsmeyer–Peppas model. The research was further validated and confirmed by the high prognostic ability of response surface methodology (RSM) with a resultant mean percentage error of (±SD) 0.17 ± 0.093 suggesting that RSM may be an efficient tool for the development and optimization of topical formulations.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Drug Development and Industrial Pharmacy, Fauzee, A.F.B., Khamanga, S.M. and Walker, R.B., 2014. The impact of manufacturing variables on in vitro release of clobetasol 17-propionate from pilot scale cream formulations. Drug development and industrial pharmacy, 40(12), pp.1683-1692, Drug Development and Industrial Pharmacy volume 40 number 12 p.1683 2014 1520-5762
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
Walker, Roderick Bryan (Prof)
Khamanga, Sandile S M (Assoc Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | The impact of formulation variables on the optimization of pilot scale clobetasol 17-propionate creams.pdf | 8 MB | Adobe Acrobat PDF | View Details |