- Title
- Evaluation of rate of swelling and erosion of verapamil (VRP) sustained-release matrix tablets
- Creator
- Khamanga, Sandile M, Walker, Roderick B
- Subject
- To be catalogued
- Date
- 2006
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/184232
- Identifier
- vital:44192
- Identifier
- xlink:href="https://doi.org/10.1080/03639040600599822"
- Description
- Tablets manufactured in-house were compared to a marketed sustained-release product of verapamil to investigate the rate of hydration, erosion, and drug-release mechanism by measuring the wet and subsequent dry weights of the products. Swelling and erosion rates depended on the polymer and granulating fluid used, which ultimately pointed to their permeability characteristics. Erosion rate of the marketed product was highest, which suggests that the gel layer that formed around these tablets was weak as opposed to the robust and resistant layers of test products. Anomalous and near zero-order transport mechanisms were dominant in tests and commercial product, respectively.
- Format
- computer, online resource, application/pdf, 1 online resource (11 pages), pdf
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Drug Development and Industrial Pharmacy, Khamanga, S.M. and Walker, R.B., 2006. Evaluation of rate of swelling and erosion of verapamil (VRP) sustained-release matrix tablets. Drug development and industrial pharmacy, 32(10), pp.1139-1148, Drug Development and Industrial Pharmacy volume 32 number 10 p.1139 2006 1520-5762
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
Walker, Roderick Bryan (Prof)
Khamanga, Sandile S M (Assoc Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Evaluation of rate of swelling and erosion of verapamil (VRP) sustained-release matrix tablets.pdf | 438 KB | Adobe Acrobat PDF | View Details Download |