- Title
- The effect of variations in pH and temperature on stability of melatonin in aqueous solution
- Creator
- Daya, Santylal, Walker, Roderick B, Glass, Beverley D, Anoopkumar-Dukie, Shailendra
- Subject
- To be catalogued
- Date
- 2001
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/184314
- Identifier
- vital:44207
- Identifier
- xlink:href="https://doi.org/10.1034/j.1600-079x.2001.310209.x"
- Description
- Melatonin (N-acetyl-5-methoxytryptamine) has a diverse range of functions, including the control of neuroendocrine events. A number of studies have shown that melatonin may be of potential benefit for the treatment of insomnia, as well as neurodegenerative disorders. At present, there are numerous dosage forms of melatonin, with the oral route of administration being most popular. Presently, there is little information on the stability of melatonin over a pH range. With the changes in pH in the gastro-intestinal tract, as well as in different experimental conditions, information on the stability of melatonin would be important. We used a high-performance liquid chromatography method to determine the stability of melatonin solutions over a pH range (1.2–12) at room temperature and at 37°C over a period of 21 days. The results show that no melatonin degradation occurred in the first 2 days. From days 3 to 21, there was a gradual decline in melatonin at all pHs, with the decline not exceeding 30%. No decline in melatonin levels occurred in the first 2 days at 37°C. From days 3 to 21, melatonin levels declined gradually, with the decline not exceeding 29%.
- Format
- computer, online resource, application/pdf, 1 online resource (4 pages), pdf
- Publisher
- Wiley Library Online
- Language
- English
- Relation
- Journal of Pineal Research, Daya, S., Walker, R.B., Glass, B.D. and Anoopkumar-Dukie, S., 2001. The effect of variations in pH and temperature on stability of melatonin in aqueous solution. Journal of pineal research, 31(2), pp.155-158, Journal of Pineal Research volume 31 number 2 p.155 2001 0742-3098
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
Daya, Santylal (Prof)
Walker, Roderick Bryan (Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | The effect of variations in pH and temperature on stability of melatonin in aqueous solution.pdf | 699 KB | Adobe Acrobat PDF | View Details |