- Title
- Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin
- Creator
- Daya, Santylal, Walker, Roderick B, Anoopkumar-Dukie, Shailendra
- Subject
- To be catalogued
- Date
- 2000
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/184346
- Identifier
- vital:44210
- Identifier
- xlink:href="https://doi.org/10.1007/BF02674529"
- Description
- The neuroprotective properties of aspirin were investigated using cyanide-induced neurotoxicity as model. Cyanide, a known neurotoxic agent significantly increased lipid peroxidation and superoxide anion levels in rat brain homogenate in a concentration-dependent manner (0.25–1.0 mM). When homogenate, containing 1.0 mM KCN was cotreated with aspirin (1.0 mM) there was a significant decrease in lipid peroxidation. Aspirin (0.5 mM and 1.0 mM) also significantly reduced KCN-induced superoxide anion generation. The results of the present report therefore indicate a neuroprotective role for aspirin.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- SpringerLink
- Language
- English
- Relation
- Metabolic Brain Disease, Daya, S., Walker, R.B. and Anoopkumar-Dukie, S., 2000. Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin. Metabolic Brain Disease, 15(3), pp.203-210, Metabolic Brain Disease volume 15 number 3 p.203 2000 1573-7365
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
- Rights
- Open Access
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Collections
Daya, Santylal (Prof)
Walker, Roderick Bryan (Prof)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin.pdf | 471 KB | Adobe Acrobat PDF | View Details |