- Title
- The effects of the composition and structure of quantum dots combined with cobalt phthalocyanine and an aptamer on the electrochemical detection of prostate specific antigen
- Creator
- Nxele, Siphesihle R, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/185002
- Identifier
- vital:44315
- Identifier
- xlink:href="https://doi.org/10.1016/j.dyepig.2021.109407"
- Description
- The ability to functionalize and modify graphene-based quantum dots has also allowed for the tuning of their activity in different applications. A comparative study is carried out in this work where a prostate specific aptamer (PSA) and cobalt phthalocyanine molecule are combined with graphene quantum dots (GQDs), nitrogen doped graphene quantum dots (NGQDs) and graphitic carbon nitride quantum dots (gCNQDs) in order to determine the effects of quantum dots type (and therefore composition) on the electrocatalytic ability of the sensor to detect the analyte of interest. For the detection of prostate-specific antigen, electrochemical impedance spectroscopy (EIS) is employed to determine detection limits as well as sensitivity and selectivity of the aptasensors. Results showed a good performance of all sensors fabricated with the NGQDs based aptasensor showing the best performance with a detection limit of 1.54 pM in EIS as well as negligible interference in mixed samples. This electrode was further verified in spiked human serum samples and good recovery and low detection limits were determined, putting this aptasensor in good stead as a reliable, efficient PSA aptasensor.
- Format
- computer, online resource, application/pdf, 1 online resource (14 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Dyes and Pigments, Nxele, S.R. and Nyokong, T., 2021. The effects of the composition and structure of quantum dots combined with cobalt phthalocyanine and an aptamer on the electrochemical detection of prostate specific antigen. Dyes and Pigments, 192, p.109407, Dyes and Pigments volume 192 p. 109407 2021 0143-7208
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
- Hits: 552
- Visitors: 625
- Downloads: 84
Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | The effects of the composition and structure of quantum dots combined with cobalt phthalocyanine and an aptamer on the electrochemical detection of prostate specific a.pdf | 831 KB | Adobe Acrobat PDF | View Details |