Synthesis of a near infrared-actuated phthalocyanine-lipid vesicle system for augmented photodynamic therapy

Nwahara, Namdi; Britton, Jonathan

Title: Synthesis of a near infrared-actuated phthalocyanine-lipid vesicle system for augmented photodynamic therapy
Creator: Nwahara, Namdi, Managa, Muthumuni, Stoffels, Mihlali, Britton, Jonathan, Prinsloo, Earl, Nyokong, Tebello
Subject: To be catalogued
Date: 2021
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/185395
Identifier: vital:44383
Identifier: xlink:href="https://doi.org/10.1016/j.synthmet.2021.116811"
Description: The efficacy of photodynamic therapy (PDT) is often limited by the poor bio-distributive properties of conventional photosensitizers and the local hypoxic microenvironment that characterises most solid tumours. Herein, a novel in situ oxygenic lipid formulation for photodynamic therapy (PDT) is reported. Such a hybrid was synthesized by adsorbing bimetallic nanozyme, MnO2@PtNPs (NPs = nanoparticles) onto graphene quantum dots (GQDs) – zinc (II) phthalocyanine conjugates, followed by liposomal encapsulation, affording it enhanced water solubility. The MnO2@PtNPs, which are is shown to possess excellent catalase-like properties surpassing that of MnO2 or PtNPs alone, serves to catalyze H2O2 to O2, while the zinc (II) phthalocyanine (1) serves to transform the formed oxygen to generate cytotoxic singlet oxygen immediately. We show that by combining each function of the respective building blocks, the as-synthesized 1-GQDs-MnO2@PtNPs-liposomes not only maintains the properties of oxygen supplementation through H2O2 catalysis but also displays cooperative properties for enhanced singlet oxygen production. Consequently, a remarkably improved PDT efficacy was observed for 1-GQDs-MnO2@PtNPs-liposomes in both normoxia and hypoxia. These results demonstrate the potential applicability of such nanozyme constituted 1-GQDs-MnO2@PtNPs-liposomes for achieving tumour treatment in hypoxic conditions by PDT.
Format: computer, online resource, application/pdf, 1 online resource (14 pages), pdf
Publisher: Elsevier
Language: English
Relation: Synethtic Metals, Nwahara, N., Managa, M., Stoffels, M., Britton, J., Prinsloo, E. and Nyokong, T., 2021. Synthesis of a near infrared-actuated phthalocyanine-lipid vesicle system for augmented photodynamic therapy. Synthetic Metals, 278, p.116811, Synethtic Metals volume 278 p. 116811 2021 0379-6779
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
Rights: Closed Access

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