- Title
- Photodynamic therapy activities of phthalocyanine-based macromolecular photosensitizers on MCF-7 breast cancer cells
- Creator
- Ahmetali, Erem, Sen, Pinar, Süer, N Ceren, Nyokong, Tebello, Erin, Tarik, Sener, M Kasim
- Subject
- To be catalogued
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/185655
- Identifier
- vital:44407
- Identifier
- xlink:href="https://doi.org/10.1080/10601325.2021.1934012"
- Description
- Poly(oxanorbornene)s with zinc(II) phthalocyanine side chains have been synthesized by ring-opening metathesis polymerization. The incorporation of zinc(II) phthalocyanine into cationic polymer has given poly(oxanorbornene)s noteworthy photophysicochemical properties and the capacity to generate singlet oxygen under light irradiation. To investigate photosensitizer’s properties of the newly synthesized polymers P6 and P7: fluorescence (ΦF), singlet oxygen (ΦΔ) and triplet (ΦT) quantum yields of polymers have been measured in dimethyl sulfoxide and aqueous medium. Singlet oxygen quantum yields of P6 and P7 have been found to be 0.22 and 0.20 in dimethyl sulfoxide, respectively. Then, photodynamic therapy activities of polymers (P1-P7) against human breast adenocarcinoma cell line (MCF-7 cells) have been investigated. The copolymer P5 bearing pendant zinc(II) phthalocyanine and triethyl phosphonium functionalities has showed enhanced PDT activity with less than 10% viable cells at 60 μg/mL.
- Format
- computer, online resource, application/pdf, 1 online resource (10 pages), pdf
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Journal of Macromolecular Science, Part A, Ahmetali, E., Sen, P., Süer, N.C., Nyokong, T., Eren, T. and Şener, M.K., 2021. Photodynamic therapy activities of phthalocyanine-based macromolecular photosensitizers on MCF-7 breast cancer cells. Journal of Macromolecular Science, Part A, pp.1-10, Journal of Macromolecular Science, Part A p. 1 2021 1520-5738
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Photodynamic therapy activities of phthalocyanine-based macromolecular photosensitizers.pdf | 2 MB | Adobe Acrobat PDF | View Details Download |