- Title
- The antibacterial and antifungal properties of neutral, octacationic and hexadecacationic Zn phthalocyanines when conjugated to silver nanoparticles
- Creator
- Mapukata, Sibusisiwe, Sen, Pinar, Osifeko, Olawale L, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/185667
- Identifier
- vital:44408
- Identifier
- xlink:href="https://doi.org/10.1016/j.pdpdt.2021.102361"
- Description
- The syntheses and characterization of novel octacationic and hexadecacationic Pcs is reported. With the aim of enhancing singlet oxygen generation efficiencies and hence antimicrobial activities, these Pcs (including their neutral counterpart) are conjugated to Ag nanoparticles (AgNPs). The obtained results show that the conjugate composed of the neutral Pc has a higher loading of Pcs as well as a greater singlet oxygen quantum yield enhancement (in the presence of AgNPs) in DMSO. The antimicrobial efficiencies of the Pcs and their conjugates were evaluated and compared on S. aureus, E. coli and C. albicans. The cationic Pcs possess better activity than the neutral Pc against all the microorganisms with the hexadecacationic Pc being the best. This work therefore demonstrates that increase in the number of cationic charges on the reported Pcs results in enhanced antimicrobial activities, which is maintained even when conjugated to Ag nanoparticles. The high activity and lack of selectivity of the cationic Pcs when conjugated to Ag NPs against different microorganisms make them good candidates for real life antimicrobial treatments.
- Format
- computer, online resource, application/pdf, 1 online resource (11 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Photodiagnosis and Photodynamic Therapy, Mapukata, S., Sen, P., Osifeko, O.L. and Nyokong, T., 2021. The antibacterial and antifungal properties of neutral, octacationic and hexadecacationic Zn phthalocyanines when conjugated to silver nanoparticles. Photodiagnosis and Photodynamic Therapy, p.102361, Photodiagnosis and Photodynamic Therapy p. 102361 2021 1572-1000
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | The antibacterial and antifungal properties of neutral, octacationic and hexadecacationic.pdf | 830 KB | Adobe Acrobat PDF | View Details Download |