- Title
- Photodynamic activity of Sn (IV) tetrathien-2-ylchlorin against MCF-7 breast cancer cells
- Creator
- Babu, Balaji, Mack, John, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/185920
- Identifier
- vital:44448
- Identifier
- xlink:href="https://doi.org/10.1039/d0dt03958f"
- Description
- A new readily-synthesized Sn(IV) tetraarylchlorin with thien-2-yl substituents (SnC) has been prepared and fully characterized by various spectroscopic techniques and its photophysical and photochemical properties, such as the singlet oxygen quantum yield (ΦΔ), fluorescence quantum yield (ΦF), triplet lifetime (τT) and photostability, have been evaluated. SnC has an unusually high ΦΔ value of 0.89 in DMF. Studies on the photodynamic activity against MCF-7 breast cancer cells exhibited a very low IC50 value of 0.9 μM and high phototoxicity (dark versus light) indices of >27.8 after irradiation with a 660 nm Thorlabs LED (280 mW cm−2). The results demonstrate that Sn(IV) tetraarylchlorins of this type are suitable candidates for further in-depth PDT studies.
- Format
- computer, online resource, application/pdf, 1 online resource (6 pages), pdf
- Publisher
- Royal Society of Chemistry
- Language
- English
- Relation
- Dalton Transactions, Babu, B., Mack, J. and Nyokong, T., 2021. Photodynamic activity of Sn (IV) tetrathien-2-ylchlorin against MCF-7 breast cancer cells. Dalton Transactions, 50(6), pp.2177-2182, Dalton Transactions volume 50 number 6 p. 2177 2021 1369-9261
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Royal Society of Chemistry Terms and Conditions Statement (https://0-www.rsc.org.wam.seals.ac.za/help-legal/)
- Rights
- Open Access
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Collections
Mack, John (Associate Prof)
Nyokong, Tebello (Distinguished Professor)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU Department of Chemistry
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