- Title
- Photophysico-chemical properties and photoinactivation of Staphylococcus Aureus using zinc phthalocyanines linked silver nanoparticles conjugates
- Creator
- Matlou, Gauta G, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/186278
- Identifier
- vital:44481
- Identifier
- xlink:href="https://doi.org/10.1016/j.dyepig.2020.108237"
- Description
- The synthesis of zinc (II) tri (tert-butyl phenoxy) mono cinnamic acid Pc (complex 1) is reported for the first time in this work. Complex 1 and the reported zinc (II) tri (tert-butyl), mono cinnamic acid phthalocyanine (2), zinc (II) mono cinnamic acid substituted phthalocyanine (3) and zinc (II) tetra cinnamic acid substituted phthalocyanine (4) are conjugated to cysteine capped silver nanoparticles (cys-AgNPs) through an amide bond. The photophysicochemical properties and the photodynamic antimicrobial chemotherapy (PACT) activities of the Pc-cys-AgNPs conjugates and the Pcs alone on S. Aureus are reported. Improved triplet and singlet oxygen quantum yields were observed for the conjugated complexes compared to Pcs alone, due to the heavy atom effect of cys-AgNPs. Asymmetric complexes 1,2, 3 and their respective conjugates recorded higher photosensitizing properties and PACT activities compared to 4 and 4-cys-AgNPs, respectively. Higher log reductions and percentage reductions of S. Aureus were recorded for conjugated complexes compared to ZnPcs only, showing enhanced PACT activities due to their higher singlet oxygen quantum yields.
- Format
- computer, online resource, application/pdf, 1 online resource (11 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Dyes and Pigments, Matlou, G.G. and Nyokong, T., 2020. Photophysico-chemical properties and photoinactivation of Staphylococcus Aureus using zinc phthalocyanines linked silver nanoparticles conjugates. Dyes and Pigments, 176, p.108237, Dyes and Pigments volume 176 p. 108237 2020 0143-7208
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Nyokong, Tebello (Distinguished Professor)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Photophysico-chemical properties and photoinactivation of Staphylococcus Aureus.pdf | 777 KB | Adobe Acrobat PDF | View Details |