- Title
- Photodynamic antimicrobial chemotherapy of asymmetric porphyrin-silver conjugates towards photoinactivation of Staphylococcus aureus
- Creator
- Shabangu, Samuel M, Babu, Balaji, Soy, Rodah C, Managa, Muthumuni, Sekhosana, Kutloano E, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/186536
- Identifier
- vital:44509
- Identifier
- xlink:href="https://doi.org/10.1080/00958972.2020.1739273"
- Description
- Asymmetric mono-carboxy-porphyrins, (5-(4-carboxyphenyl)10,15, 20-tris(pentafluorophenyl)porphyrinato zinc(II) (1), 5-(4- carboxyphenyl)10,15,20-triphenylporphyrinato zinc(II) (2) and 5-(4- carboxyphenyl)10,15,20-tris(2-thienyl)porphyrinato zinc(II) (3), were linked to Ag nanoparticles (AgNPs) through amide bonds and selfassembly (the latter only for 3). The porphyrins and conjugates were used for photodynamic antimicrobial chemotherapy (PACT) against Staphylococcus aureus. PACT uses singlet oxygen for antimicrobial activity. Complex 3 and its conjugates had higher singlet oxygen quantum yields and higher log reduction when compared with the rest of the porphyrins and corresponding conjugates. These high log reductions for 3 and its conjugate were attributed to the presence of sulfur groups whereby there was more interaction with the bacterial membrane.
- Format
- computer, online resource, application/pdf, 1 online resource (17 pages), pdf
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Journal of Coordination Chemistry, Shabangu, S.M., Babu, B., Soy, R.C., Managa, M., Sekhosana, K.E. and Nyokong, T., 2020. Photodynamic antimicrobial chemotherapy of asymmetric porphyrin-silver conjugates towards photoinactivation of Staphylococcus aureus. Journal of Coordination Chemistry, 73(4), pp.593-608, Journal of Coordination Chemistry volume 73 number 4 p. 593 2020 1029-0389
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
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