- Title
- The modulation of the photophysical and photodynamic therapy activities of a phthalocyanine by detonation nanodiamonds: Comparison with graphene quantum dots and carbon nanodots
- Creator
- Matshitse, Refilwe, Managa, Muthumuni, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/186690
- Identifier
- vital:44525
- Identifier
- xlink:href="https://doi.org/10.1016/j.diamond.2019.107617"
- Description
- A positively charged phthalocyanine (2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]-phthalocyanine (ZnTPPcQ)) was non-covalently linked to carbon based nanoparticles: detonation nanodiamonds (DNDs), carbon dots (CDs) and graphene quantum dots (GQDs) to form nanosembles of DNDs-ZnTPPcQ, GQDs-ZnTPPcQ and CDs-ZnTPPcQ, respectively. Irrespective of its small size and the least number of Pcs (41.67 μg loading per milligram of DNDs), DNDs-ZnTPPcQ gave the highest singlet oxygen quantum yield (0.62) in dimethyl sulfoxide compared to the rest of the conjugates. This resulted in superior PDT activity against MCF7 breast cancer lines, with the lowest cell viability of 28% compared to ZnTPPcQ-CDs and ZnTPPcQ-GQDs at 30.1 ± 0.02% and 31.4 ± 0.23%, respectively.
- Format
- computer, online resource, application/pdf, 1 online resource (10 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Diamond and Related Materials, Matshitse, R., Managa, M. and Nyokong, T., 2020. The modulation of the photophysical and photodynamic therapy activities of a phthalocyanine by detonation nanodiamonds: Comparison with graphene quantum dots and carbon nanodots. Diamond and Related Materials, 101, p.107617, Diamond and Related Materials volume 101 p. 107617 2021 0925-9635
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | The modulation of the photophysical and photodynamic therapy activities of a phthalocyanine by detonation nanodiamonds.pdf | 695 KB | Adobe Acrobat PDF | View Details Download |