- Title
- The photophysicochemical properties and photodynamic therapy activity of phenyldiazenyl phenoxy substituted phthalocyanines when incorporated into Pluronic® F127 micelles
- Creator
- Motloung, Banele M, Sekhosana, Kutloano E, Managa, Muthumuni, Prinsloo, Earl, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/186769
- Identifier
- vital:44532
- Identifier
- xlink:href="https://doi.org/10.1016/j.poly.2019.114157"
- Description
- The synthesis, photophysicochemical properties and photodynamic activity (PDT) of 4(4-phenyldiazenyl) phenoxy substituted indium (III) (InPc) and zinc (ZnPc) phthalocyanines when alone or incorporated into Pluronic_ F127 micelles are presented in this study. The InPc exhibited higher singlet oxygen (UD) at 0.47 compared to the ZnPc at 0.20 in dimethylsulfoxide. The UD values in the presence of Pluronic_ F127 and in water, were 0.32 for InPc and 0.09 for ZnPc. The triplet quantum yields (UT) were 0.92 for InPc and 0.32 for ZnPc in DMSO. The PDT activity followed the same trend as the singlet oxygen quantum yields. At the highest concentration, InPc in Pluronic_ F127 gave 22% cell viability compared to 34% for complex ZnPc. The partition coefficient Kp values were determined using the water and octanol system. InPc had a larger Kp suggesting that it is more likely to be taken up by the cancer cells, hence it exhibited better PDT activity.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Polyhedron, Motloung, B.M., Sekhosana, K.E., Managa, M., Prinsloo, E. and Nyokong, T., 2019. The photophysicochemical properties and photodynamic therapy activity of phenyldiazenyl phenoxy substituted phthalocyanines when incorporated into Pluronic® F127 micelles. Polyhedron, 174, p.114157, Polyhedron volume 174 p. 114157 2019 0277-5387
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Prinsloo, Earl (Dr)
RU DST/NRF SARChI for Biotechnology Innovation and Engagement
RU Department of Chemistry
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | The photophysicochemical properties and photodynamic therapy activity of phenyldiazenyl phenoxy substituted phthalocyanines.pdf | 781 KB | Adobe Acrobat PDF | View Details |