- Title
- Synthesis, characterization and photodynamic activity of Sn (iv) triarylcorroles with red-shifted Q bands
- Creator
- Babu, Balaji, Prinsloo, Earl, Mack, John, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/187521
- Identifier
- vital:44668
- Identifier
- xlink:href="https://doi.org/10.1039/C9NJ03391B"
- Description
- Two Sn(IV) triarylcorroles were synthesised and characterized. The absorption spectrum of a meso-thien-2-yl substituted tin(IV)corrole (1-Sn) is red shifted compared to its phenyl analogue (2-Sn) and shows no sign of aggregation in solution. 1-Sn and 2-Sn exhibited singlet oxygen quantum yields of 0.87 and 0.54 in DMF, and have a triplet lifetime of 31 and 50 μs, respectively. Time dependent cellular uptake in MCF-7 cells for 1-Sn reached a peak at 24 h, and 1-Sn was found to be more lipophilic than 2-Sn. 1-Sn showed good photo-cytotoxicity on exposure to a Thorlabs 625 nm LED with an IC50 value of 3.2 μM and remained inactive in the dark.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- Royal Society of Chemistry
- Language
- English
- Relation
- New Journal of Chemistry, Babu, B., Prinsloo, E., Mack, J. and Nyokong, T., 2019. Synthesis, characterization and photodynamic activity of Sn (iv) triarylcorroles with red-shifted Q bands. New Journal of Chemistry, 43(47), pp.18805-18812, New Journal of Chemistry volume 43 number 47 p. 18805 2019 1369-9261
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Royal Society of Chemistry Terms and Conditions Statement (https://0-www.rsc.org.wam.seals.ac.za/help-legal/)
- Rights
- Open Access
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Collections
Prinsloo, Earl (Dr)
RU DST/NRF SARChI for Biotechnology Innovation and Engagement
Mack, John (Associate Prof)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 09. Industry, Innovation and Infrastructure
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details | SOURCE1 | Synthesis, characterization and photodynamic activity of Sn (iv) triarylcorroles with red-shifted Q bands.pdf | 2 MB | Adobe Acrobat PDF | View Details |