- Title
- Effect of number of positive charges on the photophysical and photodynamic therapy activities of quarternary benzothiazole substituted zinc phthalocyanine
- Creator
- Matshitse, Refilwe, Nwaji, Njemuwa, Mananga, Muthumuni, Prinsloo, Earl, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/187819
- Identifier
- vital:44700
- Identifier
- xlink:href="https://doi.org/10.1016/j.jphotochem.2018.08.033"
- Description
- The synthesis, photophysicochemical and photodynamic therapy (PDT) activity of quaternary benzothiazole substituted zinc phthalocyanine (2, containing two charges, and 3, containing four charges) are reported in this work. Furthermore, the activity of the synthesized complex was compared to non-quaternary derivative (1). Higher triplet and singlet oxygen quantum yields of 0.92 and 0.85, respectively, for quaternized complexes 2 and 3 compared to complex 1 alone. Complexes 1, 2 and 3 showed relatively no dark toxicity against the epithelial breast cancer cells with cell survival of above 90 ± 3%. The quaternary derivatives (2 and 3) showed superior PDT activity with 30% or less of viable cells at concentration of 50.0 μg/mL in comparison to complex 1 alone which further lay credence to the importance of quaternization in the enhancement of PDT activity.
- Format
- computer, online resource, application/pdf, 1 online resource (8 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Photochemistry and Photobiology A: Chemistry, Matshitse, R., Nwaji, N., Mananga, M., Prinsloo, E. and Nyokong, T., 2018. Effect of number of positive charges on the photophysical and photodynamic therapy activities of quarternary benzothiazole substituted zinc phthalocyanine. Journal of Photochemistry and Photobiology A: Chemistry, 367, pp.253-260, Journal of Photochemistry and Photobiology A: Chemistry volume 367 p. 253 2018 1010-6030
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
Prinsloo, Earl (Dr)
RU DST/NRF SARChI for Biotechnology Innovation and Engagement
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 09. Industry, Innovation and Infrastructure
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Effect of number of positive charges on the photophysical and photodynamic therapy activities.pdf | 690 KB | Adobe Acrobat PDF | View Details Download |