- Title
- Improving singlet oxygen generating abilities of phthalocyanines
- Creator
- Nwahara, Nnamdi, Britton, Jonathan, Nyokong, Tebello
- Subject
- To be catalogued
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/188943
- Identifier
- vital:44800
- Identifier
- xlink:href="https://doi.org/10.1080/00958972.2017.1313975"
- Description
- Glutathione-capped graphene quantum dots (GQDs@GSH) were covalently linked to folic acid (FA). Aluminum tetrasulfonated phthalocyanine (ClAlTSPc) was then adsorbed on the GQDs@GSH-FA conjugate to form GQDs@GSH-FA/ClAlTSPc or on GQDs@GSH and pristine GQDs alone to form GQDs@GSH/ClAlTSPc and GQDs/ClAlTSPc, respectively. We report for the first time on the photophysicochemical behavior of the resulting nanoconjugates. The fluorescence quantum yields of pristine GQDs, GQDS@GSH, or GQDs@GSH-FA conjugate were quenched upon non-covalent interaction (π–π) with ClAlTSPc. There was an increase in triplet quantum yields from 0.38 for ClAlTSPc alone to 0.60, 0.75, and 0.73 when ClAlTSPc was linked to pristine GQDs, GQDs@GSH, and GQDs@GSH-FA, respectively. The singlet oxygen quantum yields also increased from 0.37 for ClAlTSPc alone to 0.42 (for ClALTSPc with pristine GQDs), 0.52 (for ClAlTSPc with GQDs@GSH), and 0.54 (for ClAlTSPc with GQDs@GSH-FA). Thus, the present work may lead to a new generation of carbon-based nanomaterial photodynamic therapy agents with overall performance superior to conventional agents in terms of singlet oxygen generation, water dispersibility, and biocompatibility.
- Format
- computer, online resource, application/pdf, 1 online resource (16 pages), pdf
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Journal of Coordination Chemistry, Nwahara, N., Britton, J. and Nyokong, T., 2017. Improving singlet oxygen generating abilities of phthalocyanines: aluminum tetrasulfonated phthalocyanine in the presence of graphene quantum dots and folic acid. Journal of Coordination Chemistry, 70(9), pp.1601-1616, Journal of Coordination Chemistry volume 70 number 9 p. 1601 2017 1029-0389
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
Britton, Jonathan (Dr)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
Nyokong, Tebello (Distinguished Professor)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Improving singlet oxygen generating abilities of phthalocyanines.pdf | 2 MB | Adobe Acrobat PDF | View Details Download |