- Title
- 5-Fu inclusion complex capped gold nanoparticles for breast cancer therapy
- Creator
- Lakkakula, Jaya R, Krause, Rui W M, Divakaran, Deepika, Barage, Sagar, Srivastava, Rohit
- Subject
- To be catalogued
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/191713
- Identifier
- vital:45150
- Identifier
- xlink:href="https://doi.org/10.1016/j.molliq.2021.117262"
- Description
- We have attempted to prolong the circulation time and increase the solubility of 5-Fluorouracil by complexing it with cyclodextrin and then further conjugating onto the gold nanoparticle to form 5Fu ICAu. The 1H NMR and molecular docking studies suggested that 5-Fu was included within the 2HP-β-CD cavity and H-5 proton probably serves as the binding site for stabilization of the inclusion complex. The 5Fu-ICAu showed higher cell inhibition rate when studied on MDA-MB-231 and MCF-7 breast cancer cell lines due to the enhanced permeability and retention (EPR) effect by allowing the selective accumulation of nanoparticles at tumor site. This unique system can serve as a novel nanocarrier for delivery of hydrophobic drugs.
- Format
- computer, online resource, application/pdf, 1 online resource (12 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Molecular Liquids, Lakkakula, J.R., Krause, R.W.M., Divakaran, D., Barage, S. and Srivastava, R., 2021. 5-Fu inclusion complex capped gold nanoparticles for breast cancer therapy. Journal of Molecular Liquids, 341, p.117262, Journal of Molecular Liquids volume 341 p. 117262 2021 0167-7322
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Krause, Rui Werner Maçedo (Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | 5-Fu inclusion complex capped gold nanoparticles for breast cancer.pdf | 760 KB | Adobe Acrobat PDF | View Details Download |