- Title
- Clinically established biodegradable long acting injectables
- Creator
- Nkanga, Christian I, Fisch, Andreas, Rad-Malkshahi, Mazda, Romic, Marieta D, Kittel, Birgit, Ullrich, Thomas, Wang, Jing, Krause, Rui W M, Adler, Sabine, Lammers, Twan, Hennink, Wim E, Ramazani, Farshad
- Subject
- To be catalogued
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/193386
- Identifier
- vital:45327
- Identifier
- xlink:href="https://doi.org/10.1016/j.addr.2020.11.008"
- Description
- Long acting injectable formulations have been developed to sustain the action of drugs in the body over desired periods of time. These delivery platforms have been utilized for both systemic and local drug delivery applications. This review gives an overview of long acting injectable systems that are currently in clinical use. These products are categorized in three different groups: biodegradable polymeric systems, including microparticles and implants; micro and nanocrystal suspensions and oil-based formulations. Furthermore, the applications of these drug delivery platforms for the management of various chronic diseases are summarized. Finally, this review addresses industrial challenges regarding the development of long acting injectable formulations.
- Format
- computer, online resource, application/pdf, 1 online resource (27 pages), pdf
- Publisher
- Elsevier
- Language
- English
- Relation
- Advanced Drug Delivery Reviews, Nkanga, C.I., Fisch, A., Rad-Malekshahi, M., Romic, M.D., Kittel, B., Ullrich, T., Wang, J., Krause, R.W.M., Adler, S., Lammers, T. and Hennink, W.E., 2020. Clinically established biodegradable long acting injectables: An industry perspective. Advanced drug delivery reviews, 167: 19-46, Advanced Drug Delivery Reviews volume 167 p. 19 2020 0169-409X
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
Krause, Rui Werner Maçedo (Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
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| View Details | SOURCE1 | Clinically established biodegradable long acting injectables.pdf | 774 KB | Adobe Acrobat PDF | View Details |